Research & Publications
While DANNALAB operates primarily as an industrial testing laboratory, we actively contribute to advancing X‑ray methodology through patents, publications, and collaborations with research institutions.
Patents
Dr. V.A. Kogan holds multiple patents in X‑ray methodology and instrumentation, contributing to advances in pharmaceutical characterization techniques.
WO2024184529A1
Title: X-ray diffraction apparatus and method for analysing packaged samples
Inventors: Vladimir Kogan, Detlef Beckers
Granted: 2024
Innovative method for non-destructive X-ray analysis of pharmaceutical products in their original packaging.
US Patent 10,359,376
Inventors: V.A. Kogan, D. Beckers
Granted: 2020
Advanced X‑ray diffraction methodology for pharmaceutical applications.
Additional Patents Filed
Two new patents filed in 2025. Multiple additional patents in X‑ray instrumentation, pattern correction algorithms, and analytical methodology for pharmaceutical characterization.
Selected Publications
2022
- "A Clean PDF Solution"
D. Beckers, T. Degen, E. Bron, M. Sadki, V. Kogan
Denver X‑Ray Conference (DXC), Denver, USA - "Nano Materials Analysis by Combination of PDF und USAXS"
D. Beckers, J. Bolze, M. Gateshki, V.A. Kogan
EPDIC17, Croatia
2019
- "Advanced XRPD system for the characterization of pharmaceutical compounds"
V.A. Kogan, D. Beckers
PPXRD conference - "Use of Cleaning Algorithm for Model‑Free Correction of Instrumental Aberrations in XRPD Patterns"
V.A. Kogan (DANNALAB B.V.), D. Beckers, A. Kharchenko (Malvern Panalytical B.V.)
PPXRD conference, Switzerland - "Instrumental Effects in Laboratory Pair Distribution Function (PDF) Analysis"
M. Gateshki, D. Beckers (Malvern Panalytical B.V.), V.A. Kogan (DANNALAB B.V.)
ECM meeting, Vienna - "Use of Pattern Correction Algorithm to Remove the Effect of Axial Divergence in Atomic Pair Distribution Function (PDF) Analysis"
D. Beckers, M. Gateshki (Malvern Panalytical B.V.), V.A. Kogan (DANNALAB B.V.)
Denver X‑Ray Conference
2018
- "High‑performance small‑ and wide‑angle X‑ray scattering (SAXS/WAXS) experiments on a multi‑functional laboratory goniometer platform with easily exchangeable X‑ray modules"
J. Bolze, V. Kogan*, M. Fransen, D. Beckers
Review of Scientific Instruments
Malvern Panalytical, *DANNALAB B.V. - Presentation at Nanotech 2018
Tokyo, Japan
2017
- "C‑terminal truncated α‑synuclein fibrils contain strongly twisted β‑sheets"
Iyer, A.; Roeters, S.; Kogan, V.; Woutersen, S.; Claessens, M.; Subramaniam, V.
Journal of the American Chemical Society - "Evidence for Intramolecular Antiparallel β‑Sheet Structure in α‑Synuclein Fibrils from a Combination of Two‑Dimensional Infrared Spectroscopy and Atomic Force Microscopy"
Roeters, S., Iyer, A., Pletikapic, G., Subramaniam, V., Woutersen, S., Kogan, V.
Nature Communications - Presentation at Nanotech 2017
Tokyo, Japan
Research Collaborations
Instrument Development
Long‑term collaboration with Malvern Panalytical (formerly PANalytical) on X‑ray instrumentation development, pattern correction algorithms, and methodology improvements.
Structural Biology
Research projects with universities on protein structure, amyloid fibril formation, and biopolymer characterization using advanced SAXS techniques.
Materials Science
Nanomaterials characterization and PDF (Pair Distribution Function) analysis for materials research applications.
European Commission
Validated by the Joint Research Centre (JRC) of the European Commission for SAXS characterization of nanoparticles.
Research Focus Areas
- XRPD Methodology — Pattern correction algorithms, instrumental aberration analysis, pharmaceutical applications
- Pair Distribution Function (PDF) — Advanced techniques for nanomaterials and disordered systems
- SAXS for Biologics — Protein structure determination, aggregation analysis, envelope reconstruction
- Instrumentation Innovation — Goniometer platforms, X‑ray modules, detection systems
- Data Analysis Software — Algorithm development for pattern cleaning, aberration correction, model fitting
- Pharmaceutical CMC — Method validation, regulatory compliance, cGMP applications
Conference Participation
DANNALAB regularly presents at international conferences including:
Denver X‑Ray Conference
Annual conference on X‑ray analysis and diffraction
PPXRD Conference
Pharmaceutical Powder X‑Ray Diffraction symposium
ECM
European Crystallographic Meeting
EPDIC
European Powder Diffraction Conference
Nanotech Japan
Nanotechnology conference and exhibition
Industrial Focus
While we contribute to research and methodology development, DANNALAB operates primarily as an industrial testing laboratory. Our research activities inform and improve the services we provide to pharmaceutical companies, ensuring access to the most advanced and reliable analytical methods.