Characterization of Nanoparticles with SAXS
Comprehensive SAXS analysis for nanoparticle identification and characterization in solid and liquid matrices — from particle size distribution to internal structure determination.
SAXS for Nanoparticles
At DANNALAB we offer a range of analytical services devoted to the identification and characterization of nanoparticles — both in solid and liquid matrices.
SAXS provides unique insights into nanoscale structure, particle distribution, and surface properties that are critical for pharmaceutical and materials applications.
Analytical Capabilities
The following properties may be investigated using our SAXS methodologies:
Nanoparticle Detection
Confirmation of the presence of nanoparticles in complex matrices, including biological matrices.
Agglomeration Effects
Investigation of particle aggregation and cluster formation in formulations and composites.
Shape & Geometry
Determination of shape and geometrical invariants such as radius of gyration (Rg) and form factors.
Internal Structure
Determination of the inner structure of core‑shell and composite nanoparticles.
Specific Surface Area
Determination of specific surfaces for nanoporous materials — critical for dissolution and bioavailability.
Particle Size Distribution
Accurate determination of particle size and size distribution with analysis of polydispersity.
Types of Nanoparticles
Inorganic Nanoparticles
Characterization of metal oxides, silica, gold, silver, and other inorganic nanoparticles for pharmaceutical and diagnostic applications.
Organic Nanoparticles
Analysis of polymeric nanoparticles, dendrimers, and organic composites.
Core‑Shell Particles
Multi‑layer structure analysis with determination of core and shell dimensions and electron density profiles.
Nanoporous Materials
Pore size distribution, specific surface area, and internal structure of mesoporous materials.
Nanocomposites
Analysis of nanoparticle distribution and organization in polymer matrices (e.g., PMMA/SiO2).
Pharmaceutical Nanoparticles
Drug nanocrystals, amorphous nanoparticles, and API nanoformulations.
Key Parameters & Analysis
Size Distribution
Number‑ and volume‑weighted particle size distributions with polydispersity index.
Radius of Gyration (Rg)
Mass‑weighted average distance from the center of mass — shape‑independent size parameter.
Specific Surface Area
Critical parameter for dissolution rate, bioavailability, and reactivity of nanomaterials.
Form Factor Analysis
Shape determination: spheres, rods, discs, ellipsoids, and complex morphologies.
Structure Factor
Interparticle interactions, spatial correlations, and ordering in concentrated systems.
Fractal Dimension
Analysis of aggregate structure and surface roughness.
SAXS Advantages for Nanoparticles
- Non‑destructive analysis — samples can be recovered after measurement
- Native environment — particles analyzed in solution, powder, or matrix without modification
- Wide size range — from 1 nm to several hundred nanometers
- Ensemble average — statistically relevant information from billions of particles
- Minimal sample preparation — simple dilution or powder mounting
- Quantitative results — absolute intensity calibration for concentration determination
- Complementary to other methods — combines well with DLS, TEM, AFM, and other techniques
Applications
Pharmaceutical Development
Nanocrystal formulations, controlled release systems, and enhanced bioavailability formulations.
Quality Control
Batch‑to‑batch consistency monitoring, stability studies, and release testing.
Formulation Optimization
Effect of processing parameters, excipients, and storage conditions on nanoparticle properties.
Biosimilars Development
Comparability studies and structural characterization of nanoparticulate systems.
Materials Research
Development of novel nanomaterials for pharmaceutical and medical device applications.
Regulatory Support
Documentation for regulatory submissions with cGMP‑compliant testing and QA‑approved deliverables.
Related Services
SAXS Method Information
Detailed technical information about our SAXS methods and capabilities.
Drug Delivery Systems
SAXS for liposomes, LNPs, and other nanoparticulate delivery carriers.
cGMP Compliance
Full details on our quality system, certifications, and regulatory compliance.
Discuss Your Nanoparticle Project
Contact our technical team to discuss your nanoparticle characterization needs, request a quote, or get expert advice on SAXS method development.