XRPD Services

X-Ray Powder Diffraction for pharmaceutical characterization, polymorph analysis, and quality control.

XRPD Applications — What We Measure

Analytical capabilities and parameters obtained by XRPD:

Polymorph Identification

Identification and quantification of polymorphic forms, hydrates, and solvates in APIs and finished products.

Crystallinity Quantification

Determination of crystalline/amorphous ratio for APIs and formulations with LOQ as low as 1% wt.

Unit Cell Identification

Indexing and unit cell determination for unknown materials, critical for patent applications.

Rietveld & Phase Analysis

Full-pattern fitting for atomic structure refinement and quantitative composition of multiphase mixtures.

Service Types — How We Support Your Development

XRPD services integrated into pharmaceutical development and manufacturing:

Method Development & Validation

Development of validated XRPD methods for polymorph quantification and crystallinity determination. ICH-compliant validation protocols.

Batch Release Testing

cGMP-compliant testing with QA-approved Certificates of Analysis for pharmaceutical batch release. Fast turnaround available.

Stability Studies

Long-term and accelerated stability testing. Detection of polymorphic transformations and degradation. Support for ICH stability protocols.

Quality Control

Routine QC testing of raw materials, intermediates, and finished products. Identity verification and specification compliance.

Instrument Specifications

  • X-ray source: Cu Kα
  • Angular range: 0-40 deg 2θ
  • Laboratory XRPD at DANNALAB facility in Enschede
  • cGMP compliance: Confirmed by Dutch Health Care Inspectorate